Endocrine Abstracts

Background: Thyroid hormones are important for normal fetal development. The aim of this prospective study was to explore whether thyroxine treated pregnant women with hypothyroidism are adequately thyroxine substituted during pregnancy.Material and method: During the years 1997–2002 119 pregnancies in 101 females with thyroid diseases were followed at the Department of Endocrinology. The diagnoses were autoimmune thyroiditis (AIT) with or without h...

Background: The NordiNet® International Outcome Study (IOS) (NCT00960128), a non-interventional study (2006–2016), assessed the effectiveness and safety of real-life treatment with Norditropin®. Out of 20,548 enrolled patients, 20,195 (paediatric/adult; 17,711/2484) were included in the full analysis set (FAS) and 12,938 (11,967/971) in the effectiveness analysis set (EAS). Outcomes were assessed in children with growth hormone deficiency (...

Background: Little is known about the long-term outcome of the thyroid function in Graves’ disease in a large epidemiological setting.Objective: The aim was to evaluate the long-term outcome of the thyroid function in patients diagnosed with Graves’ disease in Denmark in the period 1995-2018. Our research objectives were to investigate the incidence of disease, use of antithyroid drugs, radioactive iodine, thyroidectomy and levothyroxine during...

Background: Craniopharyngioma may be associated with severe morbidity. Few data exist on incidence rate (IR) and possible changes with time. The epidemiology of craniopharyngioma in Denmark has never been evaluated in detail.Objectives: To review the literature on craniopharyngioma incidence and to study the epidemiology of craniopharyngioma in Denmark during a recent 20-year period.Material and methods: Publications including data...

Introduction: Vitamin D insufficiency (25-hydroxy vitamin D <50 nmol/l) is a global health problem. Vitamin D food fortification might be the solution, but knowledge is sparse on whether fortification of various food items affects the bioavailability differently. It is generally assumed that ingesting vitamin D with a fatty meal improves the bioavailability of vitamin D. Furthermore, complex formation with whey protein isolate (WPI) may enhance the stability of vitamin D a...

Background and aims: Diabetic neuropathy is a common complication of type 1 diabetes. In this study we investigated the importance of long-term metabolic control for the development of diabetic neuropathy in patients with type 1 diabetes diagnosed in childhood.Materials and methods: Longitudinal cohort study. Twenty-five patients (9 women 16 men) were studied three times with neurophysiological measurements and clinical examinations. At baseline the pati...

Purpose: Papillary thyroid cancer (PTC) is the most common thyroid and endocrine malignancy worldwide. Vitamin D (calciferol or 25-hydroxyvitamin D) (25(OH)D) has been postulated as a key modulator in several cancer-related pathways, although its contribution to PTC still remain controversial. The aim of the study was to analyse the correlation between 25(OH)D serum levels and 25(OH)D insufficiency as well as the risk of development of PTC and its variants: classical type (CV-...

Purpose: Papillary thyroid cancer (PTC) accounts for approximately 80% of all thyroid cancers and is defined by its unique cytologic and histologic features. Mutations of the RET and BRAF/V600 genes are found in nearly 70% of PTC cases. They are able to trigger the activation of mitogen-activated protein kinase pathways and to promote neoplastic cell proliferation. Genetic events may further lead to numerous different cell variants of PTC which may be identified via t...

Objective: Vitamin D has potential immunomodulatory effects. We studied whether vitamin D3 supplementation affects the course of Graves’ disease (GD).Methods: In a double-blind, placebo-controlled design, we randomized patients with a first time diagnosis of GD hyperthyroidism to daily supplementation with vitamin D3 70 mg (2800 IU) or placebo, as add-on to standard treatment with anti-thyroid drugs (ATD). The intervention was continued 12 months af...

Introduction: Subarachnoid haemorrhage (SAH) is associated with a mortality rate of 30% and the survivors face significant morbidity including fatigue, isolation, depression and sleep disorders; factors affecting general health related quality of life (QoL). QoL is also known to be decreased in pituitary-hypothalamic insufficiency and tends to improve after treatment. SAH has been suggested to be a common cause of hypopituitarism by some whereas not by others. We aimed to inve...